By Alan R. Katritzky (ed.)
Written through demonstrated specialists within the box, the excellent stories mix descriptive chemistry and mechanistic perception and yield an knowing of the way the chemistry drives the houses. quantity ninety four of Advances in Heterocyclic Chemistry commences with a evaluate of cascade reactions on heterocyclic synthesis. The bankruptcy provides a desirable array of advanced sequences which supply effective routes to a large choice of heterocyclic platforms. the second one bankruptcy is the 12th within the sequence at the natural chemistry of heterocyclic ligands in metal complexes. the current contribution offers with the chemistry of polypyridine ligands in organomanganese and organorhenium complexes. Its present value might be measured via the truth that, of the approximately seven-hundred references, nearly part date from the final 10 years. training of aminoisoxazoles and their application within the synthesis of condensed structures also are lined. within the ultimate bankruptcy, isothiazolium salts and their use in synthesis are reviewed. Many condensed S,N-heterocyclic structures are defined during this, the 1st evaluate devoted to this topic.
* updated ends up in the topic which maintains to realize value and expand
* Makes to be had to graduate scholars and learn employees in educational and business laboratories the newest reports on wide array of heterocyclic topics
* The sequence varieties a truly gigantic database masking extensive parts of heterocyclic chemistry
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Additional info for Advances in Heterocyclic Chemistry, Vol. 94
Subjection of the silyl enol ether of 247 to modiﬁed Segusa oxidation conditions delivered 248 (85%), which was subsequently carried onto (+)-aspidospermidine. Kawasaki and Sakamoto developed a [3,3]-sigmatropic rearrangement cascade to introduce angular substituents found in several indole alkaloids. In one of the cases studied, the Claisen rearrangement was ﬁrst preceded by a Horner–Emmons oleﬁnation of indolinone 249 to give 250 (Scheme 45) (96TL7525). Isomerization of 250 provided indole 251 that then underwent a [3,3]-rearrangement to furnish 252 in 73% yield.
A NOBn NHOBn (CH3)2CHI O N Et3B PhMe 80 °C OH O N OH 457 NNPh2 O N 458 Et3B Zn(OTf)2 Et HN NPh2 Et O + N PhH 80 °C OH O N OH 459 OH 460 NNPh2 O S N O Bn 461 HN NPh2 In + i-PrI O S O N Bn H2O/MeOH 463 462 NHOBn O N NPh2 Et O OTBDPS Et3B PhMe heat 464 NHOBn Et O O OTBDPS 465 Scheme 81 In all of these cases (Schemes 80–82), the cascade begins with radical addition of a group onto the p-bond so as to position the system for a subsequent cyclization. A complimentary route to substituted heterocycles that has also been used involves an SRN1 reaction.
In this cascade sequence, the dianion of ethyl acetoacetate (272) reacted with 273 to provide furan derivative 274 (Scheme 50) which underwent a subsequent rearrangement to give 275 in 56% yield (04EJOC1897). The rearrangement of bis-allenyl disulﬁdes provides an interesting route to prepare fused thieno[3,4-c]thiophenes. Thus, Braverman reported that 276 reacted with lithium methoxide to give 280 in 70% yield (Scheme 51) (90T5759). Presumably, Sec. C] 35 THE SYNTHESIS OF HETEROCYCLES O O 1) LDA NEt2 SMe S O 2) OMe OMe 258 257 ∆ Ph Ph O Ph O S O S OMe S OMe 261 OMe 260 259 Scheme 47 O ∆ N2 X Ph N PO(OMe)2 H PO(OMe)2 PO(OMe)2 H X Ph Ph N O Ph 263 262a X = CH 262b X = N O X Ph N S N2 Bn N O Ph Ph 264 N Ph 265a X = CH 265b X = N O PO(OMe) 2 PO(OMe)2 PO(OMe) 2 ∆ S O Bn Ph N Ph 267 266 Scheme 48 allene 276 ﬁrst dimerized under the reaction conditions to generate disulﬁde 277.